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Health

Circadian Rhythm

circadian rhythm

Overview

Circadian rhythm (from the Latin circa, "about," and dies, "day") is an internal clock mechanism that oscillates with a period of roughly 24 hours. The master clock resides in the suprachiasmatic nucleus (SCN) of the brain and orchestrates sleep-wake cycles, daily body temperature variation, cortisol and melatonin secretion rhythms, and digestive activity patterns throughout the body.

Free-Running Period

When all external time cues, such as light, meals, and social schedules, are removed, the human circadian clock free-runs at a period of about 24.2 hours. Because this differs from exactly 24 hours, daily light exposure is essential to reset (entrain) the clock. Without this entrainment the internal clock drifts roughly 12 minutes later each day.

Effects of Disruption

Circadian disruption manifests as jet lag, shift-work disorder, and social jet lag. In the short term it causes sleep disturbance, impaired concentration, and digestive problems. Chronic disruption has been linked by epidemiological studies to elevated risks of cardiovascular disease, metabolic disorders, depression, and cancer. Crossing time zones and daylight saving time transitions are external perturbations that challenge circadian stability.

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