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Circadian Rhythm

circadian rhythm

Overview

Circadian rhythm (from the Latin circa, "about," and dies, "day") is an internal clock mechanism that oscillates with a period of roughly 24 hours. The master clock resides in the suprachiasmatic nucleus (SCN) of the brain and orchestrates sleep-wake cycles, daily body temperature variation, cortisol and melatonin secretion rhythms, and digestive activity patterns throughout the body.

Free-Running Period

The period the human circadian clock keeps on its own - its free-running period - averages about 24.2 hours rather than exactly 24 when measured under laboratory conditions that control for light and behavioral schedules. Because that period differs slightly from 24 hours, daily light exposure is essential to reset (entrain) the clock. Without this entrainment the internal clock drifts later by roughly 12 minutes a day, the difference between 24.2 and 24 hours.

Effects of Disruption

Circadian disruption manifests as jet lag, shift-work disorder, and social jet lag. In the short term it causes sleep disturbance, impaired concentration, and digestive problems. Chronic disruption has been linked by epidemiological studies to elevated risks of cardiovascular disease, metabolic disorders, depression, and cancer. Crossing time zones and daylight saving time transitions are external perturbations that challenge circadian stability.

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